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Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol
(2002-07-08)
Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9. The complex CDK9-cyclin T1 controls the elongation phase of ...
Immunohistochemical Expression of p16, p21, p27 and Cyclin D1 in Oral Nevi and Melanoma
(Springer, 2012)
The acquisition of abnormalities at G1/S is considered a crucial step in the genesis and progression of melanoma. The expression of cell cycle regulators has also been used in various neoplasms as an adjunct to diagnosis. ...
The genetics of hypertension modifies the renal cell replication response induced by experimental diabetes
(Amer Diabetes AssocAlexandriaEUA, 2002)
Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-04-15)
Inflammation is a process that has been actively related with the onset of several neurodegenerative disorders including Alzheimer disease (AD). However, the precise implications of inflammatory response for neurodegeneration ...